Lion’s Mane Mushroom – (Hericium erinaceu) mountain-priest mushroom or bearded tooth fungus is an edible mushroom belonging to the tooth fungus group.
(wiki) https://en.wikipedia.org/wiki/Hericium_erinaceus
- Recent evidence shows that Lion’s Mane Mushroom May be helpful for a multitude of health issues and diseases including PTSD, CPTSD, Concussions, Alzheimer’s, Dementia and many forms of Cancer. It is also suggested that it helps with immunoregulation through the nervous system, digestive system, circulatory system and the immune system. If taken regularly it can help with restoring the body, brain, liver and other organs to functioning properly.
- It is believed to be an immune booster and modulator that helps to fine tune and regulate your immune system.
- Lion’s Mane is being studied for helping with Depression and Anxiety. It contains erinacine and hericenones which can help fight depression and anxiety by increasing dopamine levels. Erinacine is form of an opiod peptide that can activate the Mu-type opioid receptors in your brain, resulting in an improved mood by inducing anti-depressant effects. Hericenones are a substance that can increase serotonin levels. Erinacines and Hericenones has the ability to cross the blood brain barrier to help induce your brain to reduce anxiety and depression as well as reduce stress levels.
- It is being studied for treating Neurodegenerative Diseases. It has been shown to be effective in preventing and treating Alzheimer’s, Parkinson’s and Dementia. Lion’s Mane has the ability to cross the blood brain barrier because it has high levels of Hericenones which are shown to activate NGF production which slows the Neurodegenerative diseases and reduce beta-amyloid proteins found in Alzheimer’s patients (which can cause brain cell damage).
- It is used to Reduce Stress. It is an effective adaptogen and has been shown to reduce stress-related damage in the hippocampus of the brain. It helps to promote healthy brain function and prevent dopamine re-uptake helping to increase motivation.
- Helps aid in blood pressure. Lion’s Mane appears to be an ACE inhibitor (which helps reduce blood pressure).
- Lion’s mane is known for it anti-inflammatory properties. In a study involving rats that were induced with a stroke, Lion’s mane reduced levels of acute inflammatory cytokines: IL-1β, IL-6, and TNF-alpha, while downregulating iNOS.
- Known to improve Glucose and Lipid Metabolism, In one study Lion’s mane was able to improve HDL-C by 31.1% and reduce LDL by 45.5% Lion’s mane has compounds like palmatic acid, threitol and D-arabinitol which may have antioxidant effects and help regulate blood lipid levels and reduce blood glucose levels.
- Believed to help speed up recovery from Nervous System Injuries. The nervous system is the largest system in our body and includes our brain, spinal cord and all the nerves that travel extensively throughout the whole body. They all work together to transmit signals that control almost every function of the body. Injuries to the brain (Concussions, Trauma, etc.) or spinal cord can cause loss of mental functions and even paralysis and take years to heal if they do. Recent research is finding that Lion’s mane mushrooms may help speed recovery of these types of injuries. It is found to stimulate growth and repair of nerve cells and the extract may also reduce the severity of brain damage from a stroke.
Lion’s Mane – Links to Published studies
- Anti-cancer potential of Hericium erinaceus extracts against particular human cancer cell lines.
https://www.researchgate.net/publication/322277322_Anticancer_potential_of_Hericium_erinaceus_extracts_against_particular_human_cancer_cell_lines - Hericenones and Erinacines: Stimulators of nerve growth factor (NGF) biosynthesis in Hericium erinaceus. https://www.researchgate.net/publication/240235316_Hericenones_and_erinacines_Stimulators_of_nerve_growth_factor_NGF_biosynthesis_in_Hericium_erinaceus
- Neuroregenerative potential of lion’s mane mushroom, Hericium erinaceus (Bull.: Fr.) Pers. (higher Basidiomycetes), in the treatment of peripheral nerve injury (review)
https://pubmed.ncbi.nlm.nih.gov/23510212/ - Hericium Erinaceus for Depressive Disorder
https://encyclopedia.pub/566 - Protective Effects of Hericium erinaceus Mycelium and Its Isolated Erinacine A against Ischemia-Injury-Induced Neuronal Cell Death via the Inhibition of iNOS/p38 MAPK and Nitrotyrosine
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4200813/ - Neuronal Health – Can Culinary and Medicinal Mushrooms Help
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3924982/ - Reduction of depression and anxiety by 4 weeks Hericium erinaceus intake
https://pubmed.ncbi.nlm.nih.gov/20834180/ - Nerve growth factor-inducing activity of Hericium erinaceus in 1321N1 human astrocytoma cells
https://pubmed.ncbi.nlm.nih.gov/18758067/ - The Neuroprotective Properties of Hericium erinaceus in Glutamate-Damaged Differentiated PC12 Cells and an Alzheimer’s Disease Mouse Model
https://pubmed.ncbi.nlm.nih.gov/21383512/ - Neurohealth Properties of Hericium erinaceus Mycelia Enriched with Erinacines
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5987239/ - Hericium erinaceus (Lion’s Mane) Mushroom Extracts Inhibit Metastasis of Cancer Cells to the Lung in CT-26 Colon Cancer-Tansplanted Mice
https://pubs.acs.org/doi/full/10.1021/jf400916c - Medicinal mushrooms as an attractive new source of natural compounds for future cancer therapy
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6044372/ - Hericium erinaceus (Lion’s Mane) mushroom extracts inhibit metastasis of cancer cells to the lung in CT-26 colon cancer-transplanted mice
https://www.ars.usda.gov/research/publications/publication/?seqNo115=295111 - Composition and Mechanism of Antitumor Effects of Hericium erinaceus Mushroom Extracts in Tumor-Bearing Mice
https://pubs.acs.org/doi/10.1021/jf201944n - Structure characterization of a novel polysaccharide from Hericium erinaceus fruiting bodies and its immunomodulatory activities
https://pubs.rsc.org/en/content/articlelanding/2018/fo/c7fo01389b - Anticancer potential of Hericium erinaceus extracts against human gastrointestinal cancers
https://pubmed.ncbi.nlm.nih.gov/24631140/ - A unique polysaccharide purified from Hericium erinaceus mycelium prevents oxidative stress induced by H2O2 in human gastric mucosa epithelium cell
https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0181546 - Therapeutic Potential of Hericium erinaceus for Depressive Disorderhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6982118/
- Hericium erinaceus Extract Reduces Anxiety and Depressive Behaviors by Promoting Hippocampal Neurogenesis in the Adult Mouse Brainhttps://pubmed.ncbi.nlm.nih.gov/29091526/
- Neurohealth Properties of Hericium erinaceus Mycelia Enriched with Erinacineshttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5987239/
- Chemical Constituents from Hericium erinaceus Promote Neuronal Survival and Potentiate Neurite Outgrowth via the TrkA/Erk1/2 Pathwayhttps://pubmed.ncbi.nlm.nih.gov/28758954/
- Hericenones and erinacines: Stimulators of nerve growth factor (NGF) biosynthesis in Hericium erinaceus
https://www.researchgate.net/publication/240235316_Hericenones_and_erinacines_Stimulators_of_nerve_growth_factor_NGF_biosynthesis_in_Hericium_erinaceus - Protective effects of Hericium erinaceus mycelium and its isolated erinacine A against ischemia-injury-induced neuronal cell death via the inhibition of iNOS/p38 MAPK and nitrotyrosine
https://pubmed.ncbi.nlm.nih.gov/25167134/ - Hericium erinaceus mycelium and its isolated erinacine A protection from MPTP-induced neurotoxicity through the ER stress, triggering an apoptosis cascade
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4797317/ - Immunomodulatory effects of Hericium erinaceus derived polysaccharides are mediated by intestinal immunology
https://pubmed.ncbi.nlm.nih.gov/28266682/